Article
[The significance of the epigenetics modifying gene mutations in acute myeloid leukemia].
Nihon rinsho. Japanese journal of clinical medicine - 1 Jun 2014
Wakita Satoshi, Yamaguchi Hiroki
Abstract excerpt
In recent years, recurrent somatic mutations in genes encoding proteins involved in DNA methylation and demethylation, and in histone modifications have been reported in myeloid malignancies. Large clinical correlative studies are beginning to clear the clinical importance, prevalence, and potential prognostic significance of these epigenetics modifying gene mutations. Additionally, recent studies shedding light...
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