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Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia

27 Apr 2015

Abstract excerpt

Acute myeloid leukemia (AML), the most prevalent acute leukemia in adults, is an aggressive hematological malignancy arising in hematopoietic stem and progenitor cells. With the exception of a few specific AML subtypes, the mainstays of treatment have not significantly changed over the last 20 years, and are still based on standard cytotoxic chemotherapy. As a result, clinical outcome remains poor for the...

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PMID: 26137202
DOI: 10.1177/2040620715577614

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