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Verapamil and its metabolite norverapamil inhibit the <i>Mycobacterium tuberculosis</i> MmpS5L5 efflux pump to potentiate the activity bedaquiline and other antitubercular drugs

2025-02-06

Abstract excerpt

Bedaquiline is the cornerstone of a new regimen for the treatment of drug-resistant tuberculosis. However, its clinical use is threatened by the emergence of bedaquiline-resistant strains of Mycobacterium tuberculosis . Bedaquiline targets mycobacterial ATP synthase but the predominant route to clinical bedaquiline resistance is via upregulation of the MmpS5L5 efflux pump due to mutations that inactivate the tran...

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Literature Corpus work
0f227767-f53c-5802-92c0-2685f4a854a7
DOI
10.1101/2025.02.06.636695
Open publication

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Verapamil and its metabolite norverapamil inhibit the <i>Mycobacterium tuberculosis</i> MmpS5L5 efflux pump to potentiate the activity bedaquiline and other antitubercular drugsDOI 10.1101/2025.02.06.636695
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