Article
Comparison of infection-neutralizing and -enhancing antibody balance induced by two distinct genotype strains of dengue virus type 1 or 3 DNA vaccines in mice.
Microbes and infection - 1 Nov 2013
Sjatha Fithriyah, Takizawa Yamato, Kotaki Tomohiro, Yamanaka Atsushi, Konishi Eiji
Abstract excerpt
Dengue viruses have spread throughout tropical and subtropical countries, and vaccine development is urgently needed. However, one concern is that induction of insufficient levels of neutralizing antibodies in vaccines may increase disease severity because of a hypothetical mechanism termed antibody-dependent enhancement of infection. This study used two distinct genotype strains of dengue virus types 1 and 3...
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