Article
Immunogenicity of a Candidate DNA Vaccine Based on the prM/E Genes of a Dengue Type 2 Virus Cosmopolitan Genotype Strain.
Japanese journal of infectious diseases - 1 Jan 2015
Putri Dwi Hilda, Sudiro Tjahjani Mirawati, Yunita Rina, Jaya Ungke Anton, Dewi Beti Ernawati, Sjatha Fithriyah, Konishi Eiji, Hotta Hak, Sudarmono Pratiwi
Abstract excerpt
The development of a dengue virus vaccine is a major priority in efforts to control the diseases. Several researchers are currently using the Asian 1 and Asian 2 genotypes as vaccine candidates for dengue type 2 virus (DENV-2). However, in this study, we constructed a recombinant plasmid-based prM/E gene, from a DENV-2 Cosmopolitan genotype strain as a dengue DNA vaccine candidate. The protein expression of the...
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