Article
Non-requirement of a regulatory subunit of Protein Phosphatase 2A, PP2A-B', for activation of Sex comb reduced activity in Drosophila melanogaster.
Mechanisms of development - 1 Jan 2000
Moazzen Hoda, Rosenfeld Robyn, Percival-Smith Anthony
Abstract excerpt
The Drosophila HOX transcription factor, Sex combs reduced (SCR), is required for determining labial and the first thoracic segmental identity. A Protein Phosphatase 2A holoenzyme assembled with the PP2A-B' regulatory subunit is proposed to specifically interact with, and dephosphorylate, the SCR homeodomain activating SCR protein activity. To test this hypothesis further, a null mutation was created in the...
Topics
- Animals
- Cell Nucleus
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Homozygote
- Male
- Models, Genetic
- Mutation
- Phenotype
- Phosphorylation
- Protein Phosphatase 2
- Protein Structure, Tertiary
- Salivary Glands
- Transcription Factors