Article
Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A.
Development (Cambridge, England) - 1 Jul 2002
Hannus Michael, Feiguin Fabian, Heisenberg Carl-Philipp, Eaton Suzanne
Abstract excerpt
We have identified widerborst (wdb), a B' regulatory subunit of PP2A, as a conserved component of planar cell polarization mechanisms in both Drosophila and in zebrafish. In Drosophila, wdb acts at two steps during planar polarization of wing epithelial cells. It is required to organize tissue polarity proteins into proximal and distal cortical domains, thus determining wing hair orientation. It is also needed to...
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