Article
BRAF mutation is associated with distinct clinicopathological characteristics in colorectal cancer: a systematic review and meta-analysis.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 1 Dec 2013
Clancy C, Burke J P, Kalady M F, Coffey J C
Abstract excerpt
AIM: Colorectal cancer is a heterogeneous disease with multiple underlying genetic mutations resulting in different phenotypes. Mutation in the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) proto-oncogene is an important event in the methylator pathway. There is no consensus, however, on the clinicopathological characteristics associated with BRAF mutation. METHOD: A comprehensive search for published...
Topics
- Age Factors
- Age of Onset
- Carcinoma
- Colonic Neoplasms
- Colorectal Neoplasms
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Mutation