Article
BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status.
Molecular cancer - 10 Jan 2006
Li Wei Qi, Kawakami Kazuyuki, Ruszkiewicz Andrew, Bennett Graeme, Moore James, Iacopetta Barry
Abstract excerpt
BACKGROUND: BRAF is a member of RAF family of serine/threonine kinases and mediates cellular responses to growth signals through the RAS-RAF-MAP kinase pathway. Activating mutations in BRAF have recently been found in about 10% of colorectal cancers, with the vast majority being a V600E hotspot mutation. The aim of the present study was to evaluate the clinical, pathological and molecular phenotype of colorectal...
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