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Article

Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas.

International journal of cancer - 10 Jan 2004

Koinuma Koji, Shitoh Kazuhisa, Miyakura Yasuyuki, Furukawa Taiji, Yamashita Yoshihiro, Ota Jun, Ohki Ruri, Choi Young Lim, Wada Tomoaki, Konishi Fumio, Nagai Hideo, Mano Hiroyuki

Abstract excerpt

Activating mutations of BRAF have been frequently observed in microsatellite unstable (MSI+) colorectal carcinomas (CRCs), in which mutations of BRAF and KRAS are mutually exclusive. Previously, we reported that hypermethylation of hMLH1 might play an important role in the tumorigenesis of right-sided sporadic CRCs with MSI showing less frequency of KRAS/TP53 alteration. Therefore, we have assumed that BRAF...

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Identifiers

PMID: 14639609
DOI: 10.1002/ijc.11523

Genes

BRAF
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas.PMID 14639609Read ↗

BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Role of the BRAF mutations in the microsatellite instability genetic pathway in sporadic colorectal cancer.Semantic proximity Read ↗

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Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high-level microsatellite instability.Semantic proximity Read ↗

The profile of hMLH1 methylation and microsatellite instability in colorectal and non-small cell lung cancer.Semantic proximity Read ↗

hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability.Semantic proximity Read ↗

Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.Semantic proximity Read ↗

Prevalence of somatic mutl homolog 1 promoter hypermethylation in Lynch syndrome colorectal cancerSemantic proximity Read ↗

The role of hypermethylation of thehMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancersSemantic proximity Read ↗

BRAF mutation in sporadic colorectal cancer and Lynch syndrome.Semantic proximity Read ↗

BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors.Semantic proximity Read ↗

Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer.Semantic proximity Read ↗

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