Article
Early neocortical regionalization in the absence of thalamic innervation.
Science (New York, N.Y.) - 6 Aug 1999
Miyashita-Lin E M, Hevner R, Wassarman K M, Martinez S, Rubenstein J L
Abstract excerpt
There is a long-standing controversy regarding the mechanisms that generate the functional subdivisions of the cerebral neocortex. One model proposes that thalamic axonal input specifies these subdivisions; the competing model postulates that patterning mechanisms intrinsic to the dorsal telencephalon generate neocortical regions. Gbx-2 mutant mice, whose thalamic differentiation is disrupted, were investigated....
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