Article
Functional effects of polymorphisms on glucocorticoid receptor modulation of human anxiogenic substance-P gene promoter activity in primary amygdala neurones.
Psychoneuroendocrinology - 1 Sept 2014
Hay Colin W, Shanley Lynne, Davidson Scott, Cowie Philip, Lear Marissa, McGuffin Peter, Riedel Gernot, McEwan Iain J, MacKenzie Alasdair
Abstract excerpt
Expression or introduction of the neuropeptide substance-P (SP; encoded by the TAC1 gene in humans and Tac1 in rodents) in the amygdala induces anxiety related behaviour in rodents. In addition, pharmacological antagonism of the main receptor of SP in humans; NK1, is anxiolytic. In the current study, we show that the Tac1 locus is up-regulated in primary rat amygdala neurones in response to activation of the...
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