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Article

Spheroid culture of LuCaP 147 as an authentic preclinical model of prostate cancer subtype with SPOP mutation and hypermutator phenotype.

Cancer letters - 1 Sept 2014

Saar Matthias, Zhao Hongjuan, Nolley Rosalie, Young Sarah R, Coleman Ilsa, Nelson Peter S, Vessella Robert L, Peehl Donna M

Abstract excerpt

LuCaP serially transplantable xenografts are valuable preclinical models of locally advanced or metastatic prostate cancer. For the first time, we recently succeeded in establishing and serially passaging spheroid cultures of several LuCaP xenografts. Here, we characterized in depth the molecular and cellular phenotype of LuCaP 147 cultures and found faithful retention of the characteristics of the original...

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Identifiers

PMID: 24998678
DOI: 10.1016/j.canlet.2014.06.014
PMCID: PMC4112013

Genes

SPOP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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