Article
The future of patient-derived xenografts in prostate cancer research.
Nature reviews. Urology - 1 Jun 2023
Lawrence Mitchell G, Taylor Renea A, Cuffe Georgia B, Ang Lisa S, Clark Ashlee K, Goode David L, Porter Laura H, Le Magnen Clémentine, Navone Nora M, Schalken Jack A, Wang Yuzhuo, van Weerden Wytske M, Corey Eva, Isaacs John T, Nelson Peter S, Risbridger Gail P
Abstract excerpt
Patient-derived xenografts (PDXs) are generated by engrafting human tumours into mice. Serially transplantable PDXs are used to study tumour biology and test therapeutics, linking the laboratory to the clinic. Although few prostate cancer PDXs are available in large repositories, over 330 prostate cancer PDXs have been established, spanning broad clinical stages, genotypes and phenotypes. Nevertheless, more PDXs...
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