Article
Patient-derived xenografts and organoids model therapy response in prostate cancer.
Nature communications - 18 Feb 2021
Karkampouna Sofia, La Manna Federico, Benjak Andrej, Kiener Mirjam, De Menna Marta, Zoni Eugenio, Grosjean Joël, Klima Irena, Garofoli Andrea, Bolis Marco, Vallerga Arianna, Theurillat Jean-Philippe, De Filippo Maria R, Genitsch Vera, Keller David, Booij Tijmen H, Stirnimann Christian U, Eng Kenneth, Sboner Andrea, Ng Charlotte K Y, Piscuoglio Salvatore, Gray Peter C, Spahn Martin, Rubin Mark A, Thalmann George N, Kruithof-de Julio Marianna
Abstract excerpt
Therapy resistance and metastatic processes in prostate cancer (PCa) remain undefined, due to lack of experimental models that mimic different disease stages. We describe an androgen-dependent PCa patient-derived xenograft (PDX) model from treatment-naïve, soft tissue metastasis (PNPCa). RNA and whole-exome sequencing of the PDX tissue and organoids confirmed transcriptomic and genomic similarity to primary...
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