Article
Lack of CHEK2 gene mutations in differentiated thyroid carcinoma patients using high resolution melting analysis.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014
Fayaz Shima, Fard-Esfahani Pezhman, Torbati Peyman Mohammadi
Abstract excerpt
Recently, mutations in the genes involved in cell cycle control, including CHEK2, are being considered as etiological factors in different kinds of cancers. The CHEK2 protein plays an important role in protecting damaged DNA from entering mitosis. In this study the potential effects of two common mutations IVS2+1G?A and Ile157Thr of CHEK2 gene in differentiated thyroid carcinoma (DTC) were evaluated. A total of...
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