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Article

CHK2 1100delC, IVS2+1G>A and I157T mutations are not present in hepatocellular cancer cases from a Turkish population.

Gene - 10 Jan 2013

Bayram Süleyman, Akkız Hikmet, Topaktaş Mehmet

Abstract excerpt

AIM: The cell cycle checkpoint kinase 2 (CHK2) protein participates in the DNA damage response in many cell types. Germline mutations in CHK2 (1100delC, IVS2+1G>A and I157T) have been associated with a range of cancer types. This study aimed to investigate whether CHK2 1100delC, IVS2+1G>A and I15...

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Identifiers

PMID: 23107771
DOI: 10.1016/j.gene.2012.10.045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23107771-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHK2 1100delC, IVS2+1G>A and I157T mutations are not present in hepatocellular cancer cases from a Turkish population.PMID 23107771Read ↗

CHEK2 1100delC, IVS2+1G>A and I157T mutations are not present in colorectal cancer cases from Turkish population.Semantic proximity Read ↗

The effect of CHEK2 variant I157T on cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis.Semantic proximity Read ↗

CHEK2 variant I157T may be associated with increased breast cancer risk.Semantic proximity Read ↗

Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.Semantic proximity Read ↗

The CHEK2 I157T variant and breast cancer susceptibility: a systematic review and meta-analysis.Semantic proximity Read ↗

The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN).Semantic proximity Read ↗

The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population.Semantic proximity Read ↗

Association of two mutations in the CHEK2 gene with breast cancer.Semantic proximity Read ↗

CHEK2 I157T and colorectal cancer in Bulgaria.Semantic proximity Read ↗

CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify the risk of sporadic pancreatic cancer.Semantic proximity Read ↗

A Comparison between CHEK2*1100delC/I157T Mutation Carrier and Noncarrier Breast Cancer Patients: A Clinicopathological Analysis.Semantic proximity Read ↗

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