Article
Detecting differential allelic expression using high-resolution melting curve analysis: application to the breast cancer susceptibility gene CHEK2.
BMC medical genomics - 11 May 2011
Nguyen-Dumont Tú, Jordheim Lars P, Michelon Jocelyne, Forey Nathalie, McKay-Chopin Sandrine, Sinilnikova Olga, Le Calvez-Kelm Florence, Southey Melissa C, Tavtigian Sean V, Lesueur Fabienne
Abstract excerpt
BACKGROUND: The gene CHEK2 encodes a checkpoint kinase playing a key role in the DNA damage pathway. Though CHEK2 has been identified as an intermediate breast cancer susceptibility gene, only a small proportion of high-risk families have been explained by genetic variants located in its coding region. Alteration in gene expression regulation provides a potential mechanism for generating disease susceptibility....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.