Article
A genome-wide interactome of DNA-associated proteins in the human liver.
Genome research - 1 Nov 2017
Ramaker Ryne C, Savic Daniel, Hardigan Andrew A, Newberry Kimberly, Cooper Gregory M, Myers Richard M, Cooper Sara J
Abstract excerpt
Large-scale efforts like the ENCODE Project have made tremendous progress in cataloging the genomic binding patterns of DNA-associated proteins (DAPs), such as transcription factors (TFs). However, most chromatin immunoprecipitation-sequencing (ChIP-seq) analyses have focused on a few immortalized cell lines whose activities and physiology differ in important ways from endogenous cells and tissues. Consequently,...
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