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Article

Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6

4 Jul 2014

Abstract excerpt

Galectin-3 has been reported to regulate the functions of a number of immune cell types. We previously reported that galectin-3 is translocated to immunological synapses in T cells upon T-cell receptor engagement, where it associates with ALG-2-interacting protein X (Alix). Alix is known to coordinate with the endosomal sorting complex required for transport (ESCRT) to promote human immunodeficiency virus (HIV)-1...

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PMID: 24996823
DOI: 10.1093/glycob/cwu064

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