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Article

The clathrin adaptor complex AP-1 binds HIV-1 and MLV Gag and facilitates their budding.

Molecular biology of the cell - 1 Aug 2007

Camus Grégory, Segura-Morales Carolina, Molle Dorothee, Lopez-Vergès Sandra, Begon-Pescia Christina, Cazevieille Chantal, Schu Peter, Bertrand Edouard, Berlioz-Torrent Clarisse, Basyuk Eugenia

Abstract excerpt

Retroviral assembly is driven by Gag, and nascent viral particles escape cells by recruiting the machinery that forms intralumenal vesicles of multivesicular bodies. In this study, we show that the clathrin adaptor complex AP-1 is involved in retroviral release. The absence of AP-1mu obtained by genetic knock-out or by RNA interference reduces budding of murine leukemia virus (MLV) and HIV-1, leading to a delay...

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Share to Endosomal Sorting Complexes Required for Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17538020
DOI: 10.1091/mbc.e06-12-1147
PMCID: PMC1949356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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