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The large extracellular loop of CD63 interacts with gp41 of HIV-1 and is essential for establishing the virological synapse

11 May 2021

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) persists lifelong in infected individuals and has evolved unique strategies in order to evade the immune system. One of these strategies is the direct cell-to-cell spread of HIV-1. The formation of a virological synapse (VS) between donor and target cell is important for this process. Tetraspanins are cellular proteins that are actively involved in the formation of a...

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PMID: 33976357
DOI: 10.1038/s41598-021-89523-7

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