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Article

Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli.

Molecular microbiology - 1 Sept 2014

Johnson Matthew D, Bell James, Clarke Kim, Chandler Rachel, Pathak Prachi, Xia Yandong, Marshall Robert L, Weinstock George M, Loman Nicholas J, Winn Peter J, Lund Peter A

Abstract excerpt

Laboratory-based evolution and whole-genome sequencing can link genotype and phenotype. We used evolution of acid resistance in exponential phase Escherichia coli to study resistance to a lethal stress. Iterative selection at pH 2.5 generated five populations that were resistant to low pH in early exponential phase. Genome sequencing revealed multiple mutations, but the only gene mutated in all strains was evgS,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24995530
DOI: 10.1111/mmi.12704
PMCID: PMC4283999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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