Article
Identification of sigma S-dependent genes associated with the stationary-phase acid-resistance phenotype of Shigella flexneri.
Molecular microbiology - 1 Sept 1996
Waterman S R, Small P L
Abstract excerpt
Shigella flexneri grown to stationary phase has the ability to survive for several hours at pH 2.5. This acid resistance, which may contribute to the low infective dose associated with shigellosis, is dependent upon the expression of the stationary-phase-specific sigma factor sigma S. Using random TnphoA and TnlacZ mutagenesis we isolated five acid-sensitive mutants of S. flexneri, which had lost their ability to...
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