Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lysyl oxidase is required for vascular and diaphragmatic development in mice.

The Journal of biological chemistry - 18 Apr 2003

Hornstra Ian K, Birge Shonyale, Starcher Barry, Bailey Allen J, Mecham Robert P, Shapiro Steven D

Abstract excerpt

Lysyl oxidase (LOX) is an enzyme responsible for the cross-linking of collagen and elastin both in vitro and in vivo. The unique functions of the individual members of this multigene family have been difficult to ascertain because of highly conserved catalytic domains and overlapping tissue expression patterns. To address this problem of functional and structural redundancy and to determine the role of LOX in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Blood Vessels
Share to Collagen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diaphragm

Share to Elastin

Share to Hydroxyproline

Share to Microscopy, Electron

Share to Protein-Lysine 6-Oxidase

Source

Identifiers

PMID: 12473682
DOI: 10.1074/jbc.M210144200

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lysyl oxidase is required for vascular and diaphragmatic development in mice.PMID 12473682Read ↗

Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice.Semantic proximity Read ↗

Mechanical behavior and matrisome gene expression in the aneurysm-prone thoracic aorta of newborn lysyl oxidase knockout mice.Semantic proximity Read ↗

Lysyl Oxidase Activity Is Dysregulated during Impaired Alveolarization of Mouse and Human LungsSemantic proximity Read ↗

Sex-Linked Skeletal Phenotype of Lysyl Oxidase Like-1 Mutant Mice.Semantic proximity Read ↗

Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans.Semantic proximity Read ↗

The Role of Lysyl Oxidase Enzymes in Cardiac Function and RemodelingSemantic proximity Read ↗

Comparative gene array analyses of severe elastic fiber defects in late embryonic and newborn mouse aortaSemantic proximity Read ↗

Functional importance of lysyl oxidase family propeptide regionsSemantic proximity Read ↗

Lysyl oxidase (LOX) in vascular remodelling. Insight from a new animal model.Semantic proximity Read ↗

Role of the lysyl oxidase enzyme family in cardiac function and diseaseSemantic proximity Read ↗

Coordination between cytoskeletal organization, cell contraction and extracellular matrix development, is depended on LOX for aneurysm preventionSemantic proximity Read ↗

Blocking Compensatory Matrix Cross-Linking Accelerates Thoracic Aortopathy in a Mouse Model of Marfan SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.