Article
Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene.
Biochemical and biophysical research communications - 1 Apr 2005
Miyata Keishi, Oike Yuichi, Hoshii Takayuki, Maekawa Hiromitsu, Ogawa Hisao, Suda Toshio, Araki Kimi, Yamamura Ken-ichi
Abstract excerpt
Multiple steps, including the migration of vascular smooth muscle cells (SMCs), are involved in the pathogenesis of atherosclerosis. To discover genes which are involved in these steps, we screened mutant mouse lines established by the exchangeable gene trap method utilizing X-gal staining during their embryonic development. One of these lines showed strong reporter gene expression in the vitelline vessels of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
