Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the lysyl oxidase enzyme family in cardiac function and disease

14 Aug 2019

Abstract excerpt

Heart diseases are a major cause of morbidity and mortality world-wide. Lysyl oxidase (LOX) and related LOX-like (LOXL) isoforms play a vital role in remodelling the extracellular matrix (ECM). The LOX family controls ECM formation by cross-linking collagen and elastin chains. LOX/LOXL proteins are copper-dependent amine oxidases that catalyse the oxidation of lysine, causing cross-linking between the lysine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Consumption and Health Effects
Share to Biochemical Acid Research Studies
Share to Microbial metabolism and enzyme function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31504232
DOI: 10.1093/cvr/cvz176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the lysyl oxidase enzyme family in cardiac function and diseasePMID 31504232Read ↗

The Role of Lysyl Oxidase Enzymes in Cardiac Function and RemodelingSemantic proximity Read ↗

Lysyl oxidase: Properties, regulation and multiple functions in biologySemantic proximity Read ↗

Linking LOXL2 to Cardiac Interstitial FibrosisSemantic proximity Read ↗

Functional importance of lysyl oxidase family propeptide regionsSemantic proximity Read ↗

Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver CancerSemantic proximity Read ↗

Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice.Semantic proximity Read ↗

Molecular Insights Into Lysyl Oxidases in Cartilage Regeneration and RejuvenationSemantic proximity Read ↗

Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor stateSemantic proximity Read ↗

A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity.Semantic proximity Read ↗

Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosisSemantic proximity Read ↗

Lysyl Oxidase Like 1: Biological roles and regulation.Semantic proximity Read ↗

LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.