Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intima modifier locus 2 controls endothelial cell activation and vascular permeability.

Physiological genomics - 1 Sept 2014

Smolock Elaine M, Burke Ryan M, Wang Chenjing, Thomas Tamlyn, Batchu Sri N, Qiu Xing, Zettel Martha, Fujiwara Keigi, Berk Bradford C, Korshunov Vyacheslav A

Abstract excerpt

Carotid intima formation is a significant risk factor for cardiovascular disease. C3H/FeJ (C3H/F) and SJL/J (SJL) inbred mouse strains differ in susceptibility to immune and vascular traits. Using a congenic approach we demonstrated that the Intima modifier 2 (Im2) locus on chromosome 11 regulates leukocyte infiltration. We sought to determine whether inflammation was due to changes in circulating immune cells or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capillary Permeability
Share to Cell Size

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Endothelium, Vascular

Share to Gene Ontology

Share to Mice, Congenic

Share to Tunica Intima

Share to Vascular Cell Adhesion Molecule-1

Source

Open in PubMed Open full text

Identifiers

PMID: 24986958
DOI: 10.1152/physiolgenomics.00048.2014
PMCID: PMC4154246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intima modifier locus 2 controls endothelial cell activation and vascular permeability.PMID 24986958Read ↗

Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening.Semantic proximity Read ↗

Genetic analysis of atherosclerosis identifies a major susceptibility locus in the major histocompatibility complex of mice.Semantic proximity Read ↗

Polygenic Control of Carotid Atherosclerosis in a BALB/cJ × SM/J Intercross and a Combined Cross Involving Multiple Mouse Strains.Semantic proximity Read ↗

Endothelial Cells retain inflammatory memory through chromatin remodelingSemantic proximity Read ↗

Identification of Mep1a as a susceptibility gene for atherosclerosis in mice.Semantic proximity Read ↗

Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease.Semantic proximity Read ↗

Transcriptome analysis of genes regulated by cholesterol loading in two strains of mouse macrophages associates lysosome pathway and ER stress response with atherosclerosis susceptibility.Semantic proximity Read ↗

Functional investigation of the coronary artery disease gene SVEP1.Semantic proximity Read ↗

Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice.Semantic proximity Read ↗

The mouse atherosclerosis locus at chromosome 10 (Ath11) acts early in lesion formation with subcongenic strains delineating 2 narrowed regions.Semantic proximity Read ↗

Direct evidence for a crucial role of the arterial wall in control of atherosclerosis susceptibility.Semantic proximity Read ↗

A major role for RCAN1 in atherosclerosis progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.