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Article

Clinical Applications of Epigenetic Markers and Epigenetic Profiling in Myeloid Malignancies

30 Jan 2012

Abstract excerpt

Aberrant DNA methylation is frequent in the myeloid malignancies, particularly myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). Promoter CpG methylation is correlated with silencing of tumor-suppressor genes (TSGs) in specific pathways that are also targets of mutation or other mechanisms of inactivation, and is thought to contribute to disease progression and poor prognosis. Epigenetic...

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PMID: 22289497
DOI: 10.1053/j.seminoncol.2011.11.003

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