Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct antifibrogenic effects of erlotinib, sunitinib and sorafenib on rat pancreatic stellate cells.

World journal of gastroenterology - 28 Jun 2014

Elsner Anne, Lange Falko, Fitzner Brit, Heuschkel Martin, Krause Bernd Joachim, Jaster Robert

Abstract excerpt

AIM: To study if three clinically available small molecule kinase inhibitors (SMI), erlotinib, sunitinib and sorafenib, exert antifibrogenic effects on pancreatic stellate cells (PSC) and analyze the basis of their action. METHODS: Cultured rat PSC were exposed to SMI. Cell proliferation and viability were assessed employing 5-bromo-2'-deoxyuridine incorporation assay and flow cytometry, respectively....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen Type I, alpha 1 Chain
Share to Matrix Metalloproteinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Niacinamide

Share to Phenylurea Compounds

Share to Pyrroles

Share to Rats, Inbred Lew

Share to Sorafenib

Share to Sunitinib

Source

Open in PubMed Open full text

Identifiers

PMID: 24976727
DOI: 10.3748/wjg.v20.i24.7914
PMCID: PMC4069318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct antifibrogenic effects of erlotinib, sunitinib and sorafenib on rat pancreatic stellate cells.PMID 24976727Read ↗

Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cellsSemantic proximity Read ↗

Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling.Semantic proximity Read ↗

An immortalized rat pancreatic stellate cell line RP-2 as a new cell model for evaluating pancreatic fibrosis, inflammation and immunity.Semantic proximity Read ↗

Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis.Semantic proximity Read ↗

Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinomaSemantic proximity Read ↗

Differential roles of signaling pathways for proliferation and migration of rat pancreatic stellate cells.Semantic proximity Read ↗

Clinical significance and gene expression study of human hepatic stellate cells in HBV related-hepatocellular carcinoma.Semantic proximity Read ↗

Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Effects of Sunitinib and Other Kinase Inhibitors on Cells Harboring a PDGFRB Mutation Associated with Infantile Myofibromatosis.Semantic proximity Read ↗

Hepatic stellate cells display a functional vascular smooth muscle cell phenotype in a three-dimensional co-culture model with endothelial cells.Semantic proximity Read ↗

Epithelial to mesenchymal transition in the liver field: the double face of Everolimus in vitro.Semantic proximity Read ↗

Pancreatic Stellate Cells (PSCs) express Cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.