Article
Epithelial to mesenchymal transition in the liver field: the double face of Everolimus in vitro.
BMC gastroenterology - 14 Sept 2015
Masola Valentina, Carraro Amedeo, Zaza Gianluigi, Bellin Gloria, Montin Umberto, Violi Paola, Lupo Antonio, Tedeschi Umberto
Abstract excerpt
BACKGROUND: Everolimus (EVE), a mammalian target of rapamycin inhibitor, has been proposed as liver transplant immunosuppressive drug, gaining wide interest also for the treatment of cancer. Although an appropriate tolerance, it may induce several adverse effects, such as fibro-interstitial pneumonitis due to the acquisition of activated myofibroblasts. The exact molecular mechanism associated with epithelial to...
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