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Article

Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2004

Armstrong Thomas, Packham Graham, Murphy Lindsay B, Bateman Adrian C, Conti John A, Fine David R, Johnson Colin D, Benyon R Christopher, Iredale John P

Abstract excerpt

PURPOSE: The purpose of this study was to determine the role of functional interactions between pancreatic cancer cells and pancreatic stellate cells (PSCs) in the formation of the desmoplastic reaction (DR) in pancreatic cancer and to characterize the effect of type I collagen (the predominant component of the DR) on pancreatic cancer cell phenotype. EXPERIMENTAL DESIGN: PSCs and type I collagen were identified...

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Source

Identifiers

PMID: 15534120
DOI: 10.1158/1078-0432.CCR-03-0825

Genes

MIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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