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Article

Increased FGF8 signaling promotes chondrogenic rather than osteogenic development in the embryonic skull.

Disease models & mechanisms - 15 Jun 2018

Schmidt Linnea, Taiyab Aftab, Melvin Vida Senkus, Jones Kenneth L, Williams Trevor

Abstract excerpt

The bones of the cranial vault are formed directly from mesenchymal cells through intramembranous ossification rather than via a cartilage intermediate. Formation and growth of the skull bones involves the interaction of multiple cell-cell signaling pathways, with fibroblast growth factors (FGFs) and their receptors exerting a prominent influence. Mutations within the FGF signaling pathway are the most frequent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29752281
DOI: 10.1242/dmm.031526
PMCID: PMC6031357

Genes

FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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