Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease.

Neurobiology of aging - 1 Sept 2014

Poirier Judes, Miron Justin, Picard Cynthia, Gormley Patrick, Théroux Louise, Breitner John, Dea Doris

Abstract excerpt

The discovery that the apolipoprotein E (apoE) ε4 allele is genetically linked to both sporadic and familial late-onset Alzheimer's disease (AD) raises the possibility that a dysfunction of the lipid transport system could seriously affect lipid homeostasis in the brain of AD subjects. The presence of the ε4 allele has been associated with lower levels of apoE in both serum and brain tissues of normal and AD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Anticholesteremic Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Homeostasis

Share to Lipid Metabolism

Share to Peptide Fragments

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24973118
DOI: 10.1016/j.neurobiolaging.2014.03.037
PMCID: PMC5140289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease.PMID 24973118Read ↗

Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E4 as a target for developing new therapeutics for Alzheimer's disease.Semantic proximity Read ↗

APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and TherapeuticsSemantic proximity Read ↗

Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence.Semantic proximity Read ↗

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease.Semantic proximity Read ↗

<i>APOE</i> ε4: The most prevalent yet understudied risk factor for Alzheimer's diseaseSemantic proximity Read ↗

Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small moleculesSemantic proximity Read ↗

Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognitionSemantic proximity Read ↗

Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer's disease.Semantic proximity Read ↗

In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology.Semantic proximity Read ↗

Imipramine and Olanzapine Block Apoe4-Catalyzed Polymerization of Aβ and Show Evidence of Improving Alzheimer’s Disease CognitionSemantic proximity Read ↗

Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer's disease in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.