Article
Single-nucleotide polymorphisms interact to affect ADH7 transcription.
Alcoholism, clinical and experimental research - 1 Apr 2014
Jairam Sowmya, Edenberg Howard J
Abstract excerpt
BACKGROUND: The class IV alcohol dehydrogenase (ADH7, μ-ADH, σ-ADH) is important in the metabolism of ethanol and retinol. ADH7 is the only ADH not expressed in liver, instead being expressed mainly in the upper gastrointestinal tract. Genome-wide studies have identified significant associations between single-nucleotide polymorphisms in ADH7 and alcoholism and cancer, but the causative variants have not been...
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