Article
Regulation of human alcohol dehydrogenase gene ADH7: importance of an AP-1 site.
DNA and cell biology - 1 Jul 1998
Kotagiri S, Edenberg H J
Abstract excerpt
The structure and function of the human alcohol dehydrogenase 7 (ADH7) promoter were analyzed. A promoter fragment extending to bp -232 functioned well in H4IIE-C3, CV-1, and HeLa cells, whereas the region extending further upstream to bp -799 had no significant effect on activity. We identified cis-acting elements in the proximal 232 bp and examined their effect on promoter activity. Mutation of site A, where...
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