Article

miR-29c promotes alcohol dehydrogenase gene cluster expression by activating the enhancer within ADH6

2022-04-20

Abstract excerpt

Alcohol dehydrogenases (ADHs) play vital roles in alcohol metabolism and alcohol toxicity, yet little is known about miRNA-mediated regulation of ADH gene cluster. Here, we showed that miR-29c might activate ADH gene cluster transcription by targeting an enhancer element within ADH6 gene. miR-29c is differentially expressed in alcoholic liver disease. Following biochemical and molecular evidences demonstrated that...

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Literature Corpus work: 02bffd67-88fb-549d-9d57-f8b6ca35b913
DOI: 10.21203/rs.3.rs-1563020/v1

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