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Article

Hepatitis B viral core protein disrupts human host gene expression by binding to promoter regions

1 Jan 2012

Abstract excerpt

BACKGROUND: The core protein (HBc) of hepatitis B virus (HBV) has been implicated in the malignant transformation of chronically-infected hepatocytes and displays pleiotropic functions, including RNA- and DNA-binding activities. However, the mechanism by which HBc interacts with the human genome to exert effects on hepatocyte function remains unknown. This study investigated the distribution of HBc binding to...

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PMID: 23088787
DOI: 10.1186/1471-2164-13-563

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