Article
Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens.
Genetic epidemiology - 1 Jul 2014
Rubicz Rohina, Yolken Robert, Alaedini Armin, Drigalenko Eugene, Charlesworth Jac C, Carless Melanie A, Severance Emily G, Krivogorsky Bogdana, Dyer Thomas D, Kent Jack W, Curran Joanne E, Johnson Matthew P, Cole Shelley A, Almasy Laura, Moses Eric K, Blangero John, Göring Harald H H
Abstract excerpt
Increased immunoglobulin G (IgG) response to dietary antigens can be associated with gastrointestinal dysfunction and autoimmunity. The underlying processes contributing to these adverse reactions remain largely unknown, and it is likely that genetic factors play a role. Here, we estimate heritability and attempt to localize genetic factors influencing IgG antibody levels against food-derived antigens using an...
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