Article
Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids.
Developmental cell - 23 Jun 2014
Hofbauer Harald F, Schopf Florian H, Schleifer Hannes, Knittelfelder Oskar L, Pieber Bartholomäus, Rechberger Gerald N, Wolinski Heimo, Gaspar Maria L, Kappe C Oliver, Stadlmann Johannes, Mechtler Karl, Zenz Alexandra, Lohner Karl, Tehlivets Oksana, Henry Susan A, Kohlwein Sepp D
Abstract excerpt
Membrane phospholipids typically contain fatty acids (FAs) of 16 and 18 carbon atoms. This particular chain length is evolutionarily highly conserved and presumably provides maximum stability and dynamic properties to biological membranes in response to nutritional or environmental cues. Here, we show that the relative proportion of C16 versus C18 FAs is regulated by the activity of acetyl-CoA carboxylase (Acc1),...
Topics
- AMP-Activated Protein Kinases
- Acetyltransferases
- Endoplasmic Reticulum
- Fatty Acids
- Gene Expression Regulation, Fungal
- Membrane Lipids
- Mutation
- Myo-Inositol-1-Phosphate Synthase