Article
Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid.
Science (New York, N.Y.) - 11 Jun 2004
Loewen C J R, Gaspar M L, Jesch S A, Delon C, Ktistakis N T, Henry S A, Levine T P
Abstract excerpt
Cells regulate the biophysical properties of their membranes by coordinated synthesis of different classes of lipids. Here, we identified a highly dynamic feedback mechanism by which the budding yeast Saccharomyces cerevisiae can regulate phospholipid biosynthesis. Phosphatidic acid on the endoplasmic reticulum directly bound to the soluble transcriptional repressor Opi1p to maintain it as inactive outside the...
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