Article
Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4.
Journal of cell science - 15 Nov 2006
Milger Katrin, Herrmann Thomas, Becker Christiane, Gotthardt Daniel, Zickwolf Jelena, Ehehalt Robert, Watkins Paul A, Stremmel Wolfgang, Füllekrug Joachim
Abstract excerpt
Long-chain fatty acids are important metabolites for the generation of energy and the biosynthesis of lipids. The molecular mechanism of their cellular uptake has remained controversial. The fatty acid transport protein (FATP) family has been named according to its proposed function in mediating this process at the plasma membrane. Here, we show that FATP4 is in fact localized to the endoplasmic reticulum and not...
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