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Article

Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2014

Neukomm Lukas J, Burdett Thomas C, Gonzalez Michael A, Züchner Stephan, Freeman Marc R

Abstract excerpt

Axons damaged by acute injury, toxic insults, or neurodegenerative diseases execute a poorly defined autodestruction signaling pathway leading to widespread fragmentation and functional loss. Here, we describe an approach to study Wallerian degeneration in the Drosophila L1 wing vein that allows for analysis of axon degenerative phenotypes with single-axon resolution in vivo. This method allows for the axotomy of...

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Identifiers

PMID: 24958874
DOI: 10.1073/pnas.1406230111
PMCID: PMC4103363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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