Article

Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology and neurodegeneration

2025-07-02

Abstract excerpt

Nerve fibres (aka axons) are the slender, up-to-meter-long processes of nerve cells that wire nervous systems. These delicate structures must survive for an organism’s lifetime, making them prime lesion sites in neurodegeneration. Their long-term maintenance requires the homeostasis of complex local cell biology upheld by motor protein-driven transport along microtubule bundles that run uninterrupted along axons....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3643051c-1a13-5a1b-8122-1945641c59ca
DOI: 10.1101/2025.06.27.662005

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology and neurodegenerationDOI 10.1101/2025.06.27.662005Read

Different mechanisms link gain and loss of kinesin functions to axonal degenerationSemantic proximity Read

New cell biological explanations for kinesin-linked axon degenerationSemantic proximity Read

Periodic actin structures in neuronal axons are required to maintain microtubulesSemantic proximity Read

Microtubule decay is a driver of neuronal ageing and a promising target for interventionSemantic proximity Read

Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila.Semantic proximity Read

Loss of MEC-17 leads to microtubule instability and axonal degeneration.Semantic proximity Read

Re-evaluating the actin-dependence of spectraplakin functions during axon growth and maintenanceSemantic proximity Read

The Long Haul: Microtubule Motors as the Essential Supply Line for Neuronal Longevity.Semantic proximity Read

The genetics of axonal transport and axonal transport disorders.Semantic proximity Read

Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster.Semantic proximity Read

β-Tubulin mutations that cause severe neuropathies disrupt axonal transport.Semantic proximity Read

Effects of mutating α-tubulin lysine 40 on sensory dendrite development.Semantic proximity Read