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Article

VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2.

Angiogenesis - 1 Oct 2014

Han Chul, Choe Se-Woon, Kim Yong Hwan, Acharya Abhinav P, Keselowsky Benjamin G, Sorg Brian S, Lee Young-Jae, Oh S Paul

Abstract excerpt

Arteriovenous malformation (AVM) refers to a vascular anomaly where arteries and veins are directly connected through a complex, tangled web of abnormal AV fistulae without a normal capillary network. Hereditary hemorrhagic telangiectasia (HHT) types 1 and 2 arise from heterozygous mutations in endoglin (ENG) and activin receptor-like kinase 1 (ALK1), respectively. HHT patients possess AVMs in various organs, and...

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Share to Arteriovenous Malformations

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Neovascularization, Pathologic

Share to Telangiectasia, Hereditary Hemorrhagic

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Source

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Identifiers

PMID: 24957885
DOI: 10.1007/s10456-014-9436-3
PMCID: PMC4177352

Genes

ENG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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