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Article

Anti-angiogenic therapeutic strategies in hereditary hemorrhagic telangiectasia

11 Feb 2015

Abstract excerpt

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular dysplastic disorder, characterized by recurrent nosebleeds (epistaxis), multiple telangiectases and arteriovenous malformations (AVMs) in major organs. Mutations in Endoglin (ENG or CD105) and Activin receptor-like kinase 1 (ACVRL1 or ALK1) genes of the TGF-β superfamily receptors are responsible for HHT1 and HHT2 respectively and...

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Share to Tracheal and airway disorders
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PMID: 25717337
DOI: 10.3389/fgene.2015.00035

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