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Article

Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines.

Bioorganic & medicinal chemistry letters - 1 Aug 2014

Cheeseman Matthew D, Faisal Amir, Rayter Sydonia, Barbeau Olivier R, Kalusa Andrew, Westlake Maura, Burke Rosemary, Swan Michael, van Montfort Rob, Linardopoulos Spiros, Jones Keith

Abstract excerpt

The metal-dependent phosphatase PPM1D (WIP1) is an important oncogene in cancer, with over-expression of the protein being associated with significantly worse clinical outcomes. In this communication we describe the discovery and optimization of novel 2,4-bisarylthiazoles that phenocopy the knockdown of PPM1D, without inhibiting its phosphatase activity. These compounds cause growth inhibition at nanomolar...

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Identifiers

PMID: 24953599
DOI: 10.1016/j.bmcl.2014.05.067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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