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Article

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells.

Oncotarget - 30 Jun 2014

Montavon Gisèle, Jauquier Nicolas, Coulon Aurélie, Peuchmaur Michel, Flahaut Marjorie, Bourloud Katia Balmas, Yan Pu, Delattre Olivier, Sommer Lukas, Joseph Jean-Marc, Janoueix-Lerosey Isabelle, Gross Nicole, Mühlethaler-Mottet Annick

Abstract excerpt

The anaplastic lymphoma kinase (ALK) gene is overexpressed, mutated or amplified in most neuroblastoma (NB), a pediatric neural crest-derived embryonal tumor. The two most frequent mutations, ALK-F1174L and ALK-R1275Q, contribute to NB tumorigenesis in mouse models, and cooperate with MYCN in the oncogenic process. However, the precise role of activating ALK mutations or ALK-wt overexpression in NB tumor...

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Source

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Identifiers

PMID: 24947326
DOI: 10.18632/oncotarget.2036
PMCID: PMC4147337

Genes

ALK
MYCN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells.PMID 24947326Read ↗

ALK R1275Q mutation drives expansion of SCP-like cells during sympathoadrenal commitment and primes neuroblastoma initiationSemantic proximity Read ↗

The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma.Semantic proximity Read ↗

ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.Semantic proximity Read ↗

Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells.Semantic proximity Read ↗

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