Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activated ALK Cooperates with N-Myc via Wnt/β-Catenin Signaling to Induce Neuroendocrine Prostate Cancer.

Cancer research - 15 Apr 2021

Unno Kenji, Chalmers Zachary R, Pamarthy Sahithi, Vatapalli Rajita, Rodriguez Yara, Lysy Barbara, Mok Hanlin, Sagar Vinay, Han Huiying, Yoo Young A, Ku Sheng-Yu, Beltran Himisha, Zhao Yue, Abdulkadir Sarki A

Abstract excerpt

Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer with poor prognosis, and there is a critical need for novel therapeutic approaches. NEPC is associated with molecular perturbation of several pathways, including amplification of MYCN. Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase involved in the pathogenesis of neuroblastoma and other malignancies where it...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaplastic Lymphoma Kinase
Share to Carbazoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Neuroendocrine

Share to N-Myc Proto-Oncogene Protein

Share to Neoplastic Stem Cells

Share to Neuroblastoma

Share to Piperidines

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 33637566
DOI: 10.1158/0008-5472.CAN-20-3351
PMCID: PMC8137566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activated ALK Cooperates with N-Myc via Wnt/β-Catenin Signaling to Induce Neuroendocrine Prostate Cancer.PMID 33637566Read ↗

N-Myc–mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancerSemantic proximity Read ↗

Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate CancerSemantic proximity Read ↗

FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancerSemantic proximity Read ↗

Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug TargetsSemantic proximity Read ↗

K-ras and Wnt Signaling Synergize to Accelerate Prostate Tumorigenesis in the MouseSemantic proximity Read ↗

The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressivenessSemantic proximity Read ↗

c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene NetworksSemantic proximity Read ↗

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial CellsSemantic proximity Read ↗

A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistanceSemantic proximity Read ↗

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells.Semantic proximity Read ↗

δ-Catenin, a Wnt/β-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming.Semantic proximity Read ↗

Cooperativity of c-MYC with Krüppel-Like Factor 6 Splice Variant 1 induces phenotypic plasticity and promotes prostate cancer progression and metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.