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Article

ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma

20 Dec 2013

Abstract excerpt

Human anaplastic lymphoma kinase (ALK) has been identified as an oncogene that is mutated or amplified in NBLs. To obtain a better understanding of the molecular events associated with ALK in the pathogenesis of NBL, it is necessary to clarify how ALK gene contributes to NBL progression. In the present study, we found that ALK expression was significantly high in NBL clinical samples with amplified MYCN (n = 126,...

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PMID: 24356251
DOI: 10.1038/srep03450

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